The Detroit Lions (4-1) will visit the Tampa Bay Buccaneers (3-1) in a battle between two division leaders, highlighting the Week 6 schedule (4:25 p.m. ET Sunday on FOX and the FOX Sports App).
Another key Week 6 contest features the Indianapolis Colts and Jacksonville Jaguars, the AFC South Division co-leaders at 3-2.
Closing out the slate is the Dallas Cowboys (3-2) visiting the Los Angeles Chargers (2-2) on Monday Night Football.
Here’s everything you need to know about the NFL odds for Week 6 — the point spread, moneyline and total Over/Under.
All times ET
SUNDAY’S GAMES
Ravens vs. Titans in London (9:30 a.m., NFL)
Point spread: Ravens -5.5 (Ravens favored to win by more than 5.5 points, otherwise Titans cover)
Moneyline: Ravens -255 favorites to win (bet $10 to win $13.92 total); Titans +207 underdogs to win (bet $10 to win $30.70 total)
Total scoring Over/Under: 42.5 points scored by both teams combined
Vikings at Bears (1 p.m., FOX and FOX Sports App)
Point spread: Vikings -3 (Vikings favored to win by more than 3 points, otherwise Bears cover)
Moneyline: Vikings -163 favorites to win (bet $10 to win $16.13 total); Bears +138 underdogs to win (bet $10 to win $23.80 total)
Total scoring Over/Under: 43.5 points scored by both teams combined
49ers & Chiefs swap spots in Nick’s Tiers
Nick Wright, Chris Broussard, Kevin Wildes and Greg Jennings release the latest edition of Nick’s NFL Tiers ranking all 32 teams.
49ers at Browns (1 p.m., FOX and FOX Sports App)
Point spread: 49ers -9.5 (49ers favored to win by more than 9.5 points, otherwise Browns cover)
Moneyline: 49ers -507 favorites to win (bet $10 to win $11.97 total); Browns +379 underdogs to win (bet $10 to win $47.90 total)
Total scoring Over/Under: 36 points scored by both teams combined
Saints at Texans (1 p.m., FOX and FOX Sports App)
Point spread: Saints -1.5 (Saints favored to win by more than 1.5 points, otherwise Texans cover)
Moneyline: Saints -127 favorites to win (bet $10 to win $17.87 total); Texans +107 underdogs to win (bet $10 to win $20.70 total)
Total scoring Over/Under: 42.5 points scored by both teams combined
Commanders at Falcons (1 p.m., CBS)
Point spread: Falcons -1.5 (Falcons favored to win by more than 1.5 points, otherwise Commanders cover)
Moneyline: Falcons -124 favorites to win (bet $10 to win $18.06 total); Commanders +103 underdogs to win (bet $10 to win $20.30 total)
Total scoring Over/Under: 42.5 points scored by both teams combined
Seahawks at Bengals (1 p.m., CBS)
Point spread: Bengals -3 (Bengals favored to win by more than 3 points, otherwise Seahawks cover)
Moneyline: Bengals -150 favorites to win (bet $10 to win $16.67 total); Seahawks +127 underdogs to win (bet $10 to win $22.70 total)
Total scoring Over/Under: 45 points scored by both teams combined
Panthers at Dolphins (1 p.m., CBS)
Point spread: Dolphins -14.5 (Dolphins favored to win by more than 14.5 points, otherwise Panthers cover)
Moneyline: Dolphins -1143 favorites to win (bet $10 to win $10.87 total); Panthers +708 underdogs to win (bet $10 to win $80.80 total)
Total scoring Over/Under: 47.5 points scored by both teams combined
Colts at Jaguars (1 p.m., CBS)
Point spread: Jaguars -3.5 (Jaguars favored to win by more than 3.5 points, otherwise Colts cover)
Moneyline: Jaguars -193 favorites to win (bet $10 to win $15.18 total); Colts +162 underdogs to win (bet $10 to win $26.20 total)
Total scoring Over/Under: 44 points scored by both teams combined
Patriots at Raiders (4:05 p.m., CBS)
Point spread: Raiders -3 (Raiders favored to win by more than 3 points, otherwise Patriots cover)
Moneyline: Raiders -149 favorites to win (bet $10 to win $16.71 total); Patriots +127 underdogs to win (bet $10 to win $22.70 total)
Total scoring Over/Under: 41.5 points scored by both teams combined
Cardinals at Rams (4:25 p.m., FOX and FOX Sports App)
Point spread: Rams -7 (Rams favored to win by more than 7 points, otherwise Cardinals cover)
Moneyline: Rams -313 favorites to win (bet $10 to win $13.19 total); Cardinals +249 underdogs to win (bet $10 to win $34.90 total)
Total scoring Over/Under: 47.5 points scored by both teams combined
Eagles at Jets (4:25 p.m., FOX and FOX Sports App)
Point spread: Eagles -6.5 (Eagles favored to win by more than 6.5 points, otherwise Jets cover)
Moneyline: Eagles -297 favorites to win (bet $10 to win $13.37 total); Jets +236 underdogs to win (bet $10 to win $33.60 total)
Total scoring Over/Under: 42.5 points scored by both teams combined
Lions at Buccaneers (4:25 p.m., FOX and FOX Sports App)
Point spread: Lions -3 (Lions favored to win by more than 3 points, otherwise Buccaneers cover)
Moneyline: Lions -163 favorites to win (bet $10 to win $16.17 total); Buccaneers +138 underdogs to win (bet $10 to win $23.80 total)
Total scoring Over/Under: 42.5 points scored by both teams combined
Giants at Bills (8:20 p.m., NBC)
Point spread: Bills -15 (Bills favored to win by more than 14 points, otherwise Giants cover)
Moneyline: Bills -1181 favorites to win (bet $10 to win $10.85 total); Giants +729 underdogs to win (bet $10 to win $82.90 total)
Total scoring Over/Under: 44 points scored by both teams combined
MONDAY’S GAME
Cowboys at Chargers (8:15 p.m. ET, ESPN/ABC)
Point spread: Cowboys -1.5 (Cowboys favored to win by more than 1.5 points, otherwise Chargers cover)
Moneyline: Cowboys -127 favorites to win (bet $10 to win $17.87 total); Chargers +106 underdogs to win (bet $10 to win $20.60 total)
Total scoring Over/Under: 51 points scored by both teams combined
COMPLETED GAME
Point spread: Chiefs (-10.5) cover by winning by more than 10.5 points (11)
Moneyline: Chiefs win as -633 favorites (bet $10 to win $11.58 total); Broncos were +459 underdogs (bet $10 to win $55.90 total)
Total scoring Over/Under: Under 47.5 points scored by both teams combined (27)
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